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reducing the burden of non-communicable disease (NCD) in the Asian Pacific region
Shiga University of Medical Science
Department of Health Science
MEXT:Ministry of Education, Culture, Sports, Science and Technology

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NIPPON DATA NIPPON DATA is an acronym for “The National Integrated Project for Prospective Observation Of Non-communicable Disease and its Trends in the Aged”( “NIPPON” means “Japan” in Japanese).


 These are two cohort studies based on participants in the National Surveys on Circulatory Disorders, and the National Nutritional Surveys, conducted in 1980 and 1990, respectively. The combine cohorts have follow-up almost 20,000 men and women across Japan, in order to
focus on prevention of lifestyle-related diseases and promotion of healthy aging.


 The goal of the NIPPON DATA2010 cohort study is to synthesize current evidence on prevention of lifestyle-related diseases such as diabetes mellitus and cardiovascular disease for Japanese populations by identifying determinants of those diseases. The study began in 2010 by inviting participants of the National Health and Nutritional Survey conducted by the Ministry of Health, Labour and Welfare (MHLW). With the participants’ informed consent, we were able to conduct surveys that include almost 3,000 men and women on lifestyle and related factors, and we are now actively following-up the study participants.

Epidemiological Research on Subclinical Atherosclerosis

(Electron-Beam Tomography and Risk Assessment among Japanese and US Men in the Post World War II Birth Cohort)Study

 ERA JUMP is an international collaborative study to assess measures of subclinical atherosclerosis in four cohorts using standardized methods. Participants are population-based samples of approximately 300 Caucasians in Allegheny County, Pennsylvania, U.S., 300 Koreans in Ansan, South Korea, 300 Japanese in Kusatsu, Shiga, Japan, and 300 Japanese Americans in Honolulu, Hawaii, U.S. The aims of this study are to determine the relationship of risk factors of subclinical
atherosclerosis within and across these populations.

SESSA( Shiga Epidemiological Study of Subclinical Atherosclerosis)

 SESSA is a cross-sectional and prospective cohort study in approximately 1200 community-dwelling participants randomly selected from Kusatsu City, Shiga, Japan. The aims of this study are
to examine traditional and novel risk factors that contribute to the prevalence and progression of subclinical atherosclerosis and to reveal findings that are useful for the prevention and early detection of cardiovascular diseases. The baseline survey was conducted in 2006
to 2008.The follow-up survey was began in 2010.

International and Domestic Joint Research on the Prevention and Epidemiology of Cardiovascular Disease

International Collaborative Study on Nutritional Factors and Blood Pressure

 INTERMAP was conducted to examine associations between nutritional factors and hypertension among 4,680 participants in China, Japan, UK, and US. In INTERMAP, dietary surveys and blood pressure measurements were conducted using a highly standardized protocol.
INTERLIPID, an ancillary study of INTERMAP, investigates cardiovascular risk factors in Japanese in Japan and Japanese-Americans in Hawaii.

Pooled Analyses Project of Cohort Studies of Cardiovascular Diseases Across Japan( EPOCH-JAPAN)

 This project began in 2005 with the aim to pool data from well-established cohort studies across Japan. A total of 14 cohort studies have participated in the project, providing long-term data on more than 200,000 men and women (3 million person-years) across Japan. The goal of the project is to clarify associations between risk factors and total and cardiovascular disease mortality that are less clear with smaller sample sizes.

Population-based Cardiovascular Disease Registry

Shiga Stroke Database

 The Shiga Stroke Database is a population based stroke registry in Shiga prefecture that commenced in 2012. Further information can be found on the website.
(https://cera.shiga-med.ac.jp/ssdac/index.html, Japanese language only)

Takashima CVD Registry

 The Takashima CVD Registry is a population based stroke and acute myocardial infarction (AMI) registry in Takashima city (Northwest region of Shiga prefecture). This registry was initiated in 1988. The result of the registry provides basic information on the trend of CVD.

Population-based Cohort Study of the Risk Factors for Lifestyle-related Disease

Takashima Cohort Study

 The Takashima Cohort Study is a population-based genome cohort study to help identify risk factors of lifestyle- related diseases, such as stroke, acute myocardial infarction (AMI), cancer, diabetes and dementia. This cohort study is also involved in large multi-center collaborative studies (JALS and J-MICC study).

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